PDZD3 - Na(+)/H(+) exchange regulatory cofactor NHE-RF4 - human protein (Function)
 
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PDZD3 »  Na(+)/H(+) exchange regulatory cofactor NHE-RF4  (NHERF-4)
 
Protein also known as:  Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 (NaPi-Cap2).
Gene name:  PDZD3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 5
GENE REF ISO

Function

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Overview 
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.  
2
  • CuratedUniProtKB
GO molecular function 
Guanylate cyclase inhibitor activitydefinition[GO:0030251]  
1
  • IDAUniProtKB
Ion channel inhibitor activitydefinition[GO:0008200]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIIntAct
Protein C-terminus bindingdefinition[GO:0008022]  
2
  • IPIUniProtKB
GO biological process 
cGMP-mediated signalingdefinition[GO:0019934]  
1
  • NASUniProtKB
Ion transportdefinition[GO:0006811]  
1
  • NASUniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • IDAGOC
Negative regulation of cGMP biosynthetic processdefinition[GO:0030827]  
1
  • TASUniProtKB
Negative regulation of guanylate cyclase activitydefinition[GO:0031283]  
1
  • IDAGOC
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168]  
1
  • ICUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Regulation of cyclase activitydefinition[GO:0031279]  
1
  • IDAGOC
Regulation of guanylate cyclase activitydefinition[GO:0031282]  
1
  • IDAGOC
Response to toxic substancedefinition[GO:0009636]  
1
  • TASUniProtKB
Water transportdefinition[GO:0006833]  
1
  • NASUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 79849
PRO: PR:Q86UT5