SLC51B - Organic solute transporter subunit beta - human protein (Function)
 
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Protein
Gene
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SLC51B »  Organic solute transporter subunit beta  (OST-beta)
 
Protein also known as:  Solute carrier family 51 subunit beta.
Gene name:  SLC51B
Family name: OST-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the organic solute transporter (ost) family  2.A.82.1.2  
GO molecular function 
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • Ortholog Curator
Transporter activitydefinition[GO:0005215] silver  
1
  • Ortholog Compara
GO biological process 
Bile acid and bile salt transportdefinition[GO:0015721]  
1
  • Ortholog Curator
Positive regulation of protein exit from endoplasmic reticulumdefinition[GO:0070863]  
1
  • Ortholog Curator
Positive regulation of protein glycosylationdefinition[GO:0060050]  
1
  • Ortholog Curator
Positive regulation of protein targeting to membranedefinition[GO:0090314]  
1
  • Ortholog Curator
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+123264  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: OSTbeta
GenomeRNAi: 123264
PRO: PR:Q86UW2