AACS - Acetoacetyl-CoA synthetase - human protein (Function)
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AACS »  Acetoacetyl-CoA synthetase   [ EC ]
Protein also known as:  Acyl-CoA synthetase family member 1.
Gene name:  AACS
Entry whose protein(s) existence is based on evidence at protein level
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Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Acetoacetate-CoA ligase activitydefinition[GO:0030729]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Butyrate-CoA ligase activitydefinition[GO:0047760] silver  
  • IEAOrtholog Compara
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Cellular response to cholesteroldefinition[GO:0071397] silver  
  • IEAOrtholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to testosterone stimulusdefinition[GO:0071394] silver  
  • IEAOrtholog Compara
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniProtKB KW
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to oleic aciddefinition[GO:0034201] silver  
  • IEAOrtholog Compara
Response to purine-containing compounddefinition[GO:0014074] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
White fat cell differentiationdefinition[GO:0050872] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + acetoacetate + CoA AMP + diphosphate + acetoacetyl-CoA.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathway:
Butanoate metabolism  hsa00650+65985  


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 65985
PRO: PR:Q86V21