ADIPOR2 - Adiponectin receptor protein 2 - human protein (Function)
 
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ADIPOR2 »  Adiponectin receptor protein 2
 
Protein also known as:  Progestin and adipoQ receptor family member II.
Gene name:  ADIPOR2
Family name: ADIPOR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 83 1
GENE REF ISO

Function

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Overview 
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.  
2
  • UniProtKB
GO molecular function 
Adiponectin bindingdefinition[GO:0055100] silver  
1
  • Ortholog Compara
Hormone bindingdefinition[GO:0042562]  
2
  • UniProtKB
  • RefGenome
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • RefGenome
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211]  
1
  • RefGenome
Fatty acid oxidationdefinition[GO:0019395]  
1
  • UniProtKB
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • UniProtKB
Negative regulation of cell growthdefinition[GO:0030308] silver  
1
  • Ortholog Compara
Positive regulation of glucose importdefinition[GO:0046326] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adipocytokine signaling pathway  hsa04920+79602  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADIPOR2
GenomeRNAi: 79602
PRO: PR:Q86V24
Chemistry
GuidetoPHARMACOLOGY: 650