ADIPOR2 - Adiponectin receptor protein 2 - human protein (Function)
 
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ADIPOR2 »  Adiponectin receptor protein 2
 
Protein also known as:  Progestin and adipoQ receptor family member II.
Gene name:  ADIPOR2
Family name: ADIPOR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed12802337, PubMed25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).  
4
  • UniProtKB
GO molecular function 
Adipokinetic hormone receptor activitydefinition[GO:0097003]  
1
  • UniProtKB
Adiponectin bindingdefinition[GO:0055100]  
1
  • UniProtKB
Hormone bindingdefinition[GO:0042562]  
1
  • RefGenome
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • RefGenome
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211]  
2
  • UniProtKB
  • RefGenome
Fatty acid oxidationdefinition[GO:0019395]  
1
  • UniProtKB
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • GOC
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • UniProtKB
Negative regulation of cell growthdefinition[GO:0030308] silver  
1
  • Ortholog Compara
Positive regulation of glucose importdefinition[GO:0046326] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Vascular wound healingdefinition[GO:0061042]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adipocytokine signaling pathway  hsa04920+79602  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADIPOR2
GenomeRNAi: 79602
PRO: PR:Q86V24
Chemistry
GuidetoPHARMACOLOGY: 650