ADIPOR2 - Adiponectin receptor protein 2 - human protein (Function)
 
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ADIPOR2 »  Adiponectin receptor protein 2
 
Protein also known as:  Progestin and adipoQ receptor family member II.
Gene name:  ADIPOR2
Family name: ADIPOR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.  
1
  • CuratedUniProtKB
GO molecular function 
Hormone bindingdefinition[GO:0042562]  
1
  • ISSUniProtKB
  • IBARefGenome
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Receptor activitydefinition[GO:0004872] silver  
  • IBARefGenome
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211] silver  
  • IBARefGenome
Fatty acid oxidationdefinition[GO:0019395]  
1
  • ISSUniProtKB
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • ISSUniProtKB
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Positive regulation of glucose importdefinition[GO:0046326] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adipocytokine signaling pathway  hsa04920+79602  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADIPOR2
GenomeRNAi: 79602
PRO: PR:Q86V24
Chemistry
GuidetoPHARMACOLOGY: 650