SERINC5 - Serine incorporator 5 - human protein (Function)
 
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SERINC5 »  Serine incorporator 5
 
Gene name:  SERINC5
Family name: TDE1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 4
GENE REF ISO

Function

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Overview 
Restriction factor required to restrict infectivity of gammaretroviruses, such as HIV-1: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (PubMed26416733, PubMed26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).  
4
  • UniProtKB
GO molecular function 
L-serine transmembrane transporter activitydefinition[GO:0015194]  
1
  • RefGenome
GO biological process 
Defense response to virusdefinition[GO:0051607]  
2
  • UniProtKB
Detection of virusdefinition[GO:0009597]  
2
  • UniProtKB
Innate immune responsedefinition[GO:0045087]  
2
  • UniProtKB
L-serine transportdefinition[GO:0015825]  
1
  • RefGenome
Myelinationdefinition[GO:0042552] silver  
1
  • Ortholog Compara
Phosphatidylserine metabolic processdefinition[GO:0006658]  
1
  • Ortholog Curator
Phospholipid biosynthetic processdefinition[GO:0008654]  
1
  • UniProtKB KW
Positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activitydefinition[GO:1904219]  
1
  • Ortholog Curator
Positive regulation of serine C-palmitoyltransferase activitydefinition[GO:1904222]  
1
  • Ortholog Curator
Sphingolipid metabolic processdefinition[GO:0006665] silver  
1
  • InterPro 2 GO
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 256987
PRO: PR:Q86VE9