TXNDC2 - Thioredoxin domain-containing protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
TXNDC2 »  Thioredoxin domain-containing protein 2
 
Protein also known as:  Spermatid-specific thioredoxin-1 (Sptrx-1).
Gene name:  TXNDC2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

 show evidences
Overview 
Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.  
1
  • UniProtKB
GO molecular function 
Nutrient reservoir activitydefinition[GO:0045735] silver  
1
  • InterPro 2 GO
Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptordefinition[GO:0016671]  
1
  • RefGenome
Protein disulfide isomerase activitydefinition[GO:0003756] silver  
1
  • Ortholog Compara
Protein disulfide oxidoreductase activitydefinition[GO:0015035]  
1
  • RefGenome
Thioredoxin-disulfide reductase activitydefinition[GO:0004791]  
2
  • UniProtKB
  • Ortholog Curator
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Cell redox homeostasisdefinition[GO:0045454]  
2
  • UniProtKB
  • RefGenome
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • RefGenome
Glycerol ether metabolic processdefinition[GO:0006662] silver  
1
  • InterPro 2 GO
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
4
  • GOC
  • InterPro 2 GO
  • Ortholog Curator
  • RefGenome
Protein foldingdefinition[GO:0006457]  
1
  • RefGenome
Spermatogenesisdefinition[GO:0007283]  
1
  • UniProtKB
Sulfate assimilationdefinition[GO:0000103]  
1
  • RefGenome
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TXNDC2
GenomeRNAi: 84203
PRO: PR:Q86VQ3