KCNMB4 - Calcium-activated potassium channel subunit beta-4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
KCNMB4 »  Calcium-activated potassium channel subunit beta-4
 
Protein also known as:  Calcium-activated potassium channel, subfamily M subunit beta-4.
Gene name:  KCNMB4
Family name: KCNMB (TC 8.A.14.1) » KCNMB4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 1
GENE REF ISO

Function

 show evidences
Overview 
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.  
3
  • CuratedUniProtKB
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • IDAUniProtKB
Detection of calcium iondefinition[GO:0005513]  
1
  • IDAUniProtKB
Neuronal action potentialdefinition[GO:0019228]  
1
  • IDAUniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDAGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • IDAUniProtKB
Regulation of neurotransmitter secretiondefinition[GO:0046928]  
1
  • TASUniProtKB
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+27345  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Neuronal System  REACT_13685  
Note 
Treatment with okadaic acid reduces its effect on KCNMA1.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNMB4
GenomeRNAi: 27345
PRO: PR:Q86W47