KCNMB4 - Calcium-activated potassium channel subunit beta-4 - human protein (Function)
 
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KCNMB4 »  Calcium-activated potassium channel subunit beta-4
 
Protein also known as:  Calcium-activated potassium channel, subfamily M subunit beta-4.
Gene name:  KCNMB4
Family name: KCNMB (TC 8.A.14.1) » KCNMB4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.  
4
  • UniProtKB
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • UniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • UniProtKB
Detection of calcium iondefinition[GO:0005513]  
1
  • UniProtKB
Neuronal action potentialdefinition[GO:0019228]  
1
  • UniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • GOC
  • InterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • UniProtKB
Regulation of neurotransmitter secretiondefinition[GO:0046928]  
1
  • UniProtKB
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+27345  
According to Reactome, this protein belongs to the following pathways:
Ca2+ activated K+ channels  REACT_75896  
cGMP effects  REACT_23767  
Note 
Treatment with okadaic acid reduces its effect on KCNMA1.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNMB4
GenomeRNAi: 27345
PRO: PR:Q86W47