SKAP1 - Src kinase-associated phosphoprotein 1 - human protein (Function)
 
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SKAP1 »  Src kinase-associated phosphoprotein 1
 
Protein also known as:  Src kinase-associated phosphoprotein of 55 kDa (pp55).
Gene name:  SKAP1
Family name: SKAP
Entry whose protein(s) existence is based on evidence at protein level
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1 35 2
GENE REF ISO

Function

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Overview 
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.  
5
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
SH2 domain bindingdefinition[GO:0042169]  
1
  • IDAUniProtKB
SH3 domain bindingdefinition[GO:0017124]  
1
  • TASBHF-UCL
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • ICUniProtKB
GO biological process 
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • ICGOC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • IMPUniProtKB
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SKAP1
GenomeRNAi: 8631
PRO: PR:Q86WV1