HOGA1 - 4-hydroxy-2-oxoglutarate aldolase, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
HOGA1 »  4-hydroxy-2-oxoglutarate aldolase, mitochondrial   [ EC 4.1.3.16 ]
 
Protein also known as:  Probable 2-keto-4-hydroxyglutarate aldolase (Probable KHG-aldolase).
Gene name:  HOGA1
Family name: DapA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the final step in the metabolic pathway of hydroxyproline.  
2
  • CuratedUniProtKB
GO molecular function 
4-hydroxy-2-oxoglutarate aldolase activitydefinition[GO:0008700]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
GO biological process 
4-hydroxyproline catabolic processdefinition[GO:0019470]  
1
  • IDABHF-UCL
Glyoxylate catabolic processdefinition[GO:0009436]  
1
  • IMPUniProtKB
Glyoxylate metabolic processdefinition[GO:0046487]  
1
  • IDABHF-UCL
Oxalate metabolic processdefinition[GO:0033609]  
1
  • IMPBHF-UCL
Pyruvate biosynthetic processdefinition[GO:0042866]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.3.16: 4-hydroxy-2-oxoglutarate pyruvate + glyoxylate.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by divalent cations (By similarity).  
  • CuratedUniProtKB
Pathways 
 
More information is available from:
 

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 112817
PRO: PR:Q86XE5