ANKLE2 - Ankyrin repeat and LEM domain-containing protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ANKLE2 »  Ankyrin repeat and LEM domain-containing protein 2
 
Protein also known as:  LEM domain-containing protein 4.
Gene name:  ANKLE2
Family name: ANKLE2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein phosphatase 2A bindingdefinition[GO:0051721]  
1
  • IDAUniProtKB
Protein phosphatase type 2A regulator activitydefinition[GO:0008601]  
1
  • TASUniProtKB
GO biological process 
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Mitotic nuclear envelope reassemblydefinition[GO:0007084]  
1
  • IMPUniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • IDAUniProtKB
Positive regulation of protein dephosphorylationdefinition[GO:0035307]  
1
  • IDAUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • TASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Initiation of Nuclear Envelope Reformation  REACT_160242  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23141
PRO: PR:Q86XL3