PLA2G4D - Cytosolic phospholipase A2 delta - human protein (Function)
 
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PLA2G4D »  Cytosolic phospholipase A2 delta   [ EC 3.1.1.4 ]  (cPLA2-delta)
 
Protein also known as:  Phospholipase A2 group IVD.
Gene name:  PLA2G4D
Entry whose protein(s) existence is based on evidence at protein level
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1 22 2
GENE REF ISO

Function

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Overview 
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phospholipase A2 activitydefinition[GO:0004623]  
  • IEAEC 2 GO
GO biological process 
Phospholipid catabolic processdefinition[GO:0009395] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.4: Phosphatidylcholine + H(2)O 1-acylglycerophosphocholine + a carboxylate.  
  • CuratedUniProtKB
It is regulated in the following manner
Stimulated by cytosolic Ca(2+).  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fc gamma R-mediated phagocytosis  hsa04666+283748  
According to Reactome, this protein belongs to the following pathways:
Acyl chain remodelling of PC  REACT_120829  
Acyl chain remodelling of PE  REACT_121369  
Acyl chain remodelling of PG  REACT_121324  
Acyl chain remodelling of PI  REACT_120722  
Acyl chain remodelling of PS  REACT_121384  
Hydrolysis of LPC  REACT_120977  
Synthesis of PA  REACT_120906  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 283748
PRO: PR:Q86XP0