VRK2 - Serine/threonine-protein kinase VRK2 - human protein (Function)
 
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VRK2 »  Serine/threonine-protein kinase VRK2   [ EC 2.7.11.1 ]
 
Protein also known as:  Vaccinia-related kinase 2.
Gene name:  VRK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine kinase that regulates several signal transduction pathways.  
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  • CuratedUniProtKB
Isoform  Iso 1   Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.  
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  • CuratedUniProtKB
Isoform  Iso 2   Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
GO biological process 
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
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  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
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  • TASPINC
Regulation of interleukin-1-mediated signaling pathwaydefinition[GO:2000659]  
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  • IMPUniProtKB
Regulation of MAPK cascadedefinition[GO:0043408]  
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  • IMPUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: VRK2
GenomeRNAi: 7444
PRO: PR:Q86Y07
Chemistry
GuidetoPHARMACOLOGY: 2276