VRK2 - Serine/threonine-protein kinase VRK2 - human protein (Function)
 
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VRK2 »  Serine/threonine-protein kinase VRK2   [ EC 2.7.11.1 ]
 
Protein also known as:  Vaccinia-related kinase 2.
Gene name:  VRK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine kinase that regulates several signal transduction pathways.  
  • UniProtKB
Isoform  Iso 1   Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.  
1
  • UniProtKB
Isoform  Iso 2   Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • MGI
Protein kinase bindingdefinition[GO:0019901]  
1
  • MGI
Protein serine/threonine kinase activitydefinition[GO:0004674]  
3
  • UniProtKB
GO biological process 
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • UniProtKB
Endocytosisdefinition[GO:0006897]  
1
  • RefGenome
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • RefGenome
Protein autophosphorylationdefinition[GO:0046777]  
2
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell shapedefinition[GO:0008360]  
1
  • RefGenome
Regulation of interleukin-1-mediated signaling pathwaydefinition[GO:2000659]  
1
  • UniProtKB
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • UniProtKB
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It is regulated in the following manner
RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Clearance of Nuclear Envelope Membranes from Chromatin  REACT_160251  
Initiation of Nuclear Envelope Reformation  REACT_160242  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: VRK2
GenomeRNAi: 7444
PRO: PR:Q86Y07
Chemistry
GuidetoPHARMACOLOGY: 2276