ADGRG3 - Adhesion G protein-coupled receptor G3 - human protein (Function)
 
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ADGRG3 »  Adhesion G protein-coupled receptor G3
 
Protein also known as:  G-protein coupled receptor PGR26.
Gene name:  ADGRG3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed22575658).  
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  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
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  • UniProtKB KW
GO biological process 
B cell differentiationdefinition[GO:0030183]  
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  • Ortholog Curator
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
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  • InterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
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  • UniProtKB
Negative regulation of CREB transcription factor activitydefinition[GO:0032792]  
1
  • Ortholog Curator
Negative regulation of NIK/NF-kappaB signalingdefinition[GO:1901223]  
1
  • Ortholog Curator
Regulation of cell migrationdefinition[GO:0030334]  
1
  • UniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR97
GenomeRNAi: 222487
PRO: PR:Q86Y34
Chemistry
GuidetoPHARMACOLOGY: 188