PALB2 - Partner and localizer of BRCA2 - human protein (Function)
 
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PALB2 »  Partner and localizer of BRCA2
 
Gene name:  PALB2
Entry whose protein(s) existence is based on evidence at protein level
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1 102 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.  
8
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
2
  • IDAUniProtKB
Inner cell mass cell proliferationdefinition[GO:0001833] silver  
  • IEAOrtholog Compara
Mesoderm developmentdefinition[GO:0007498] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fanconi anemia pathway  hsa03460+79728  
According to Reactome, this protein belongs to the following pathway:
DNA Repair  REACT_216  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PALB2
GenomeRNAi: 79728
PRO: PR:Q86YC2