GATAD2A - Transcriptional repressor p66-alpha - human protein (Function)
 
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Protein
Gene
References

 
GATAD2A »  Transcriptional repressor p66-alpha  (Hp66alpha)
 
Protein also known as:  GATA zinc finger domain-containing protein 2A.
Gene name:  GATAD2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 3
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • UniProtKB
Contributes to RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • RefGenome
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
DNA methylationdefinition[GO:0006306]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • RefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
HDACs deacetylate histones  R-HSA-3214815  
RNA Polymerase I Transcription Initiation  R-HSA-73762  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54815
PRO: PR:Q86YP4