MIB1 - E3 ubiquitin-protein ligase MIB1 - human protein (Function)
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MIB1 »  E3 ubiquitin-protein ligase MIB1   [ EC 6.3.2.- ]
Protein also known as:  Zinc finger ZZ type with ankyrin repeat domain protein 2.
Gene name:  MIB1
Entry whose protein(s) existence is based on evidence at protein level
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E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.  
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Ubiquitin-protein transferase activitydefinition[GO:0004842] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
Heart loopingdefinition[GO:0001947] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Neural tube formationdefinition[GO:0001841] silver  
  • IEAOrtholog Compara
Positive regulation of endocytosisdefinition[GO:0045807] silver  
  • IEAOrtholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  REACT_118614  
Constitutive Signaling by NOTCH1 HD Domain Mutants  REACT_160089  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
NOTCH2 Activation and Transmission of Signal to the Nucleus  REACT_160205  
In epilepsy brain tissue, levels of expression are increased in the cytoplasm and microsomal fractions (endoplasmic reticulum).  
  • CuratedUniProtKB


Biological process 
Notch signaling pathway  definition   [KW-0914]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: MIB1_(gene)
GenomeRNAi: 57534