HIPK1 - Homeodomain-interacting protein kinase 1 - human protein (Function)
 
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HIPK1 »  Homeodomain-interacting protein kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Nuclear body-associated kinase 2.
Gene name:  HIPK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.  
6
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB KW
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Definitive hemopoiesisdefinition[GO:0060216]  
1
  • UniProtKB
Embryonic camera-type eye morphogenesisdefinition[GO:0048596] silver  
1
  • Ortholog Compara
Embryonic retina morphogenesis in camera-type eyedefinition[GO:0060059] silver  
1
  • Ortholog Compara
Endothelial cell apoptotic processdefinition[GO:0072577]  
1
  • UniProtKB
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • UniProtKB
Eye developmentdefinition[GO:0001654]  
1
  • UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771] silver  
1
  • Ortholog Compara
Iris morphogenesisdefinition[GO:0061072] silver  
1
  • Ortholog Compara
Lens induction in camera-type eyedefinition[GO:0060235] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB KW
Regulation of tumor necrosis factor-mediated signaling pathwaydefinition[GO:0010803]  
1
  • UniProtKB
Retina layer formationdefinition[GO:0010842] silver  
1
  • Ortholog Compara
Smoothened signaling pathwaydefinition[GO:0007224] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HIPK1
GenomeRNAi: 204851
PRO: PR:Q86Z02
Chemistry
GuidetoPHARMACOLOGY: 2033