HIPK1 - Homeodomain-interacting protein kinase 1 - human protein (Function)
 
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HIPK1 »  Homeodomain-interacting protein kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Nuclear body-associated kinase 2.
Gene name:  HIPK1
Entry whose protein(s) existence is based on evidence at protein level
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1 39 4
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Definitive hemopoiesisdefinition[GO:0060216]  
1
  • ISSUniProtKB
Embryonic camera-type eye morphogenesisdefinition[GO:0048596] silver  
  • IEAOrtholog Compara
Embryonic retina morphogenesis in camera-type eyedefinition[GO:0060059] silver  
  • IEAOrtholog Compara
Endothelial cell apoptotic processdefinition[GO:0072577]  
1
  • IDAUniProtKB
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • IDAUniProtKB
Eye developmentdefinition[GO:0001654]  
1
  • ISSUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771] silver  
  • IEAOrtholog Compara
Iris morphogenesisdefinition[GO:0061072] silver  
  • IEAOrtholog Compara
Lens induction in camera-type eyedefinition[GO:0060235] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • ISSUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Protein desumoylationdefinition[GO:0016926]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Regulation of tumor necrosis factor-mediated signaling pathwaydefinition[GO:0010803]  
1
  • IDAUniProtKB
Retina layer formationdefinition[GO:0010842] silver  
  • IEAOrtholog Compara
Smoothened signaling pathwaydefinition[GO:0007224] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HIPK1
GenomeRNAi: 204851
PRO: PR:Q86Z02
Chemistry
GuidetoPHARMACOLOGY: 2033