CAMK1D - Calcium/calmodulin-dependent protein kinase type 1D - human protein (Function)
 
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CAMK1D »  Calcium/calmodulin-dependent protein kinase type 1D   [ EC 2.7.11.17 ]
 
Protein also known as:  CaMKI-like protein kinase (CKLiK).
Gene name:  CAMK1D
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 2
GENE REF ISO

Function

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Overview 
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • IEAEC 2 GO
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of CREB transcription factor activitydefinition[GO:0032793]  
1
  • IDAUniProtKB
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
  • ISSOrtholog Curator
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023]  
  • ISSOrtholog Curator
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • IMPUniProtKB
Positive regulation of respiratory burstdefinition[GO:0060267]  
1
  • IMPUniProtKB
Regulation of dendrite developmentdefinition[GO:0050773]  
1
  • IMPUniProtKB
Regulation of granulocyte chemotaxisdefinition[GO:0071622]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.17: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation.  
2
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Neurogenesis  definition   [KW-0524]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 57118
PRO: PR:Q8IU85
Chemistry
GuidetoPHARMACOLOGY: 1953