CERS3 - Ceramide synthase 3 - human protein (Function)
 
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CERS3 »  Ceramide synthase 3   [ EC 2.3.1.24 ]  (CerS3)
 
Protein also known as:  LAG1 longevity assurance homolog 3.
Gene name:  CERS3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.  
1
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Sphingosine N-acyltransferase activitydefinition[GO:0050291]  
  • IEAEC 2 GO
GO biological process 
Ceramide biosynthetic processdefinition[GO:0046513]  
1
  • IMPUniProtKB
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Acyl-CoA + dihydrosphingosine CoA + N-acyldihydrosphingosine.  
  • CuratedUniProtKB
EC 2.3.1.24: Acyl-CoA + sphingosine CoA + N-acylsphingosine.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 204219
PRO: PR:Q8IU89