SPPL2C - Signal peptide peptidase-like 2C - human protein (Function)
 
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SPPL2C »  Signal peptide peptidase-like 2C   [ EC 3.4.23.- ]  (SPPL2c)
 
Protein also known as:  Intramembrane protease 5 (IMP-5).
Gene name:  SPPL2C
Family name: Peptidase A22B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.  
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  • UniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190] silver  
1
  • InterPro 2 GO
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
GO biological process 
Not  Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • UniProtKB
Not  Membrane protein intracellular domain proteolysisdefinition[GO:0031293]  
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  • UniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 162540
PRO: PR:Q8IUH8