AEBP1 - Adipocyte enhancer-binding protein 1 - human protein (Function)
 
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Protein
Gene
References

 
AEBP1 »  Adipocyte enhancer-binding protein 1  (AE-binding protein 1)
 
Protein also known as:  Aortic carboxypeptidase-like protein.
Gene name:  AEBP1
Family name: Peptidase M14
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 32 2
GENE REF ISO

Function

 show evidences
Overview 
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Carboxypeptidase activitydefinition[GO:0004180]  
1
  • TASPINC
Metallocarboxypeptidase activitydefinition[GO:0004181] silver  
  • IEAInterPro 2 GO
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDANTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001227]  
2
  • IMPNTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription corepressor activitydefinition[GO:0003714] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell adhesiondefinition[GO:0007155] silver  
  • IEAInterPro 2 GO
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASPINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPNTNU_SB
Proteolysisdefinition[GO:0006508] silver  
  • IEAInterPro 2 GO
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Caution 
Although related to peptidase M14 family, lacks the active sites residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 165
PRO: PR:Q8IUX7