VRK3 - Inactive serine/threonine-protein kinase VRK3 - human protein (Function)
 
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VRK3 »  Inactive serine/threonine-protein kinase VRK3
 
Protein also known as:  Serine/threonine-protein pseudokinase VRK3.
Gene name:  VRK3
Entry whose protein(s) existence is based on evidence at protein level
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1 26 3
GENE REF ISO

Function

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Overview 
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAInterPro 2 GO
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373] silver  
  • IEAOrtholog Compara
Positive regulation of phosphoprotein phosphatase activitydefinition[GO:0032516] silver  
  • IEAOrtholog Compara
Caution 
Inactive as a kinase due to its inability to bind ATP (PubMed19141289).  
1
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 51231
PRO: PR:Q8IV63