CNGA4 - Cyclic nucleotide-gated cation channel alpha-4 - human protein (Function)
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CNGA4 »  Cyclic nucleotide-gated cation channel alpha-4
Protein also known as:  Cyclic nucleotide-gated channel alpha-4 (CNG4).
Gene name:  CNGA4
Entry whose protein(s) existence is based on evidence at protein level
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Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).  
  • CuratedUniProtKB
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
  • IEAUniProtKB KW
cGMP bindingdefinition[GO:0030553] silver  
  • IBARefGenome
Intracellular cAMP activated cation channel activitydefinition[GO:0005222] silver  
  • IBARefGenome
Intracellular cGMP activated cation channel activitydefinition[GO:0005223] silver  
  • IBARefGenome
Voltage-gated potassium channel activitydefinition[GO:0005249] silver  
  • IBARefGenome
GO biological process 
Phototransduction, visible lightdefinition[GO:0007603] silver  
  • IBARefGenome
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IBARefGenome
Regulation of membrane potentialdefinition[GO:0042391] silver  
  • IBARefGenome
Sensory perception of smelldefinition[GO:0007608] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding.  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathway:
Olfactory transduction  hsa04740+1262  


Biological process 
Ion transport  definition   [KW-0406]
Olfaction  definition   [KW-0552]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links