CARKD - ATP-dependent (S)-NAD(P)H-hydrate dehydratase - human protein (Function)
 
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CARKD »  ATP-dependent (S)-NAD(P)H-hydrate dehydratase   [ EC 4.2.1.93 ]
 
Protein also known as:  Carbohydrate kinase domain-containing protein.
Gene name:  CARKD
Family name: NnrD/CARKD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 4
GENE REF ISO

Function

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Overview 
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  
2
  • HAMAP-Rule
  • UniProtKB
GO molecular function 
ADP-dependent NAD(P)H-hydrate dehydratase activitydefinition[GO:0052855] silver  
1
  • InterPro 2 GO
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-dependent NAD(P)H-hydrate dehydratase activitydefinition[GO:0047453]  
1
  • EC 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Nicotinamide nucleotide metabolic processdefinition[GO:0046496]  
1
  • UniProtKB Annot
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide ADP + phosphate + NADH.  
2
  • HAMAP-Rule
  • UniProtKB
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate ADP + phosphate + NADPH.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • HAMAP-Rule
  • UniProtKB
Pathways 
 
More information is available from:
 

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CARKD
GenomeRNAi: 55739
PRO: PR:Q8IW45