ADGRA3 - Adhesion G protein-coupled receptor A3 - human protein (Function)
 
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ADGRA3 »  Adhesion G protein-coupled receptor A3
 
Protein also known as:  G-protein coupled receptor 125.
Gene name:  ADGRA3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Orphan receptor that may have a role in planar cell polarity pathway.  
2
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB KW
Isoform  Iso 3   Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
1
  • InterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Enzymatic activity 
 
More information is available from:
Note 
Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.  
1
  • UniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPR125
GenomeRNAi: 166647
PRO: PR:Q8IWK6