BRSK2 - Serine/threonine-protein kinase BRSK2 - human protein (Function)
 
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BRSK2 »  Serine/threonine-protein kinase BRSK2   [ EC 2.7.11.1 ]
 
Protein also known as:  Brain-specific serine/threonine-protein kinase 2 (BR serine/threonine-protein kinase 2).
Gene name:  BRSK2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Tau-protein kinase activitydefinition[GO:0050321]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IMPUniProtKB
Axonogenesisdefinition[GO:0007409]  
  • ISSOrtholog Curator
Establishment of cell polaritydefinition[GO:0030010]  
  • ISSOrtholog Curator
Exocytosisdefinition[GO:0006887]  
  • IEAUniProtKB KW
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • IMPUniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • IMPUniProtKB
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061178]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • CuratedUniProtKB
EC 2.7.11.26: ATP + [tau protein] ADP + [tau protein] phosphate.  
2
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-174 by STK11/LKB1.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Exocytosis  definition   [KW-0268]
Mitosis  definition   [KW-0498]
Neurogenesis  definition   [KW-0524]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BRSK2
GenomeRNAi: 9024
PRO: PR:Q8IWQ3
Chemistry
GuidetoPHARMACOLOGY: 1947