SCN4B - Sodium channel subunit beta-4 - human protein (Function)
 
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Protein
Gene
References

 
SCN4B »  Sodium channel subunit beta-4
 
Gene name:  SCN4B
Entry whose protein(s) existence is based on evidence at protein level
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1 16 3
GENE REF ISO

Function

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Overview 
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the na(+) channel auxiliary subunit 1-4 (sca-) family  8.A.17.2.2  
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Sodium channel regulator activitydefinition[GO:0017080]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • IDAUniProtKB
Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialdefinition[GO:0086006]  
1
  • IMPBHF-UCL
GO biological process 
AV node cell to bundle of His cell communicationdefinition[GO:0086067]  
1
  • IMPBHF-UCL
Cardiac muscle cell action potential involved in contractiondefinition[GO:0086002]  
1
  • IMPBHF-UCL
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Membrane depolarization during cardiac muscle cell action potentialdefinition[GO:0086012]  
1
  • IMPBHF-UCL
Positive regulation of sodium ion transportdefinition[GO:0010765]  
1
  • IDABHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of sodium ion transmembrane transporter activitydefinition[GO:2000649]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • IMPBHF-UCL
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IDABHF-UCL
Sodium ion transportdefinition[GO:0006814]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCN4B
GenomeRNAi: 6330
PRO: PR:Q8IWT1