LRRC8A - Volume-regulated anion channel subunit LRRC8A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
LRRC8A »  Volume-regulated anion channel subunit LRRC8A
 
Protein also known as:  Leucine-rich repeat-containing protein 8A.
Gene name:  LRRC8A
Family name: LRRC8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 30 1
GENE REF ISO

Function

 show evidences
Overview 
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the gap junction-forming innexin (innexin) family  1.A.25.3.1  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRRC8A
GenomeRNAi: 56262
PRO: PR:Q8IWT6