TPH2 - Tryptophan 5-hydroxylase 2 - human protein (Function)
 
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Protein
Gene
References

 
TPH2 »  Tryptophan 5-hydroxylase 2   [ EC 1.14.16.4 ]
 
Protein also known as:  Neuronal tryptophan hydroxylase.
Gene name:  TPH2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
GO molecular function 
Amino acid bindingdefinition[GO:0016597] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Tryptophan 5-monooxygenase activitydefinition[GO:0004510]  
  • IEAEC 2 GO
GO biological process 
Aromatic amino acid family metabolic processdefinition[GO:0009072] silver  
  • IEAInterPro 2 GO
Cellular response to lithium iondefinition[GO:0071285] silver  
  • IEAOrtholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Serotonin biosynthetic processdefinition[GO:0042427]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.16.4: L-tryptophan + tetrahydrobiopterin + O(2) 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.  
  • CuratedUniProtKB
It requires the following cofactor
Fe(2+) ion (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+121278  
Tryptophan metabolism  hsa00380+121278  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 41.3 uM for L-tryptophan
Vmax 833 nmol/min/mg enzyme

Keywords

Biological process 
Serotonin biosynthesis  definition   [KW-0724]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q8IWU9
Other
GeneWiki: TPH2
GenomeRNAi: 121278
PRO: PR:Q8IWU9
Chemistry
GuidetoPHARMACOLOGY: 1242