UBR1 - E3 ubiquitin-protein ligase UBR1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
UBR1 »  E3 ubiquitin-protein ligase UBR1   [ EC 6.3.2.- ]
 
Protein also known as:  Ubiquitin-protein ligase E3-alpha-I.
Gene name:  UBR1
Family name: UBR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 2
GENE REF ISO

Function

 show evidences
Overview 
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.  
4
  • CuratedUniProtKB
GO molecular function 
Leucine bindingdefinition[GO:0070728]  
1
  • IDAUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to leucinedefinition[GO:0071233]  
1
  • IDAUniProtKB
Negative regulation of TOR signalingdefinition[GO:0032007]  
1
  • IMPUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAOrtholog Compara
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBR1
GenomeRNAi: 197131
PRO: PR:Q8IWV7