SGPP2 - Sphingosine-1-phosphate phosphatase 2 - human protein (Function)
 
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Protein
Gene
References

 
SGPP2 »  Sphingosine-1-phosphate phosphatase 2   [ EC 3.1.3.- ]  (Spp2)
 
Protein also known as:  Sphingosine-1-phosphatase 2.
Gene name:  SGPP2
Entry whose protein(s) existence is based on evidence at transcript level
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1 15 2
GENE REF ISO

Function

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Overview 
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.  
2
  • CuratedUniProtKB
GO molecular function 
Sphingosine-1-phosphate phosphatase activitydefinition[GO:0042392]  
1
  • IDAUniProtKB
GO biological process 
Dephosphorylationdefinition[GO:0016311]  
1
  • IDAGOC
Sphingosine metabolic processdefinition[GO:0006670]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Sphingolipid metabolism  hsa00600+130367  
According to Reactome, this protein belongs to the following pathway:
Sphingolipid de novo biosynthesis  REACT_115810  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 130367
PRO: PR:Q8IWX5