ASXL1 - Putative Polycomb group protein ASXL1 - human protein (Function)
 
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ASXL1 »  Putative Polycomb group protein ASXL1
 
Protein also known as:  Additional sex combs-like protein 1.
Gene name:  ASXL1
Family name: Asx
Entry whose protein(s) existence is based on evidence at protein level
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1 80 2
GENE REF ISO

Function

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Overview 
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Peroxisome proliferator activated receptor bindingdefinition[GO:0042975]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
Retinoic acid receptor bindingdefinition[GO:0042974]  
  • ISSOrtholog Curator
Transcription coactivator activitydefinition[GO:0003713]  
  • ISSOrtholog Curator
Transcription corepressor activitydefinition[GO:0003714]  
  • ISSOrtholog Curator
GO biological process 
Bone developmentdefinition[GO:0060348] silver  
  • IEAOrtholog Compara
Monoubiquitinated histone H2A deubiquitinationdefinition[GO:0035522]  
1
  • IDAUniProtKB
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
  • ISSOrtholog Curator
Negative regulation of peroxisome proliferator activated receptor signaling pathwaydefinition[GO:0035359]  
  • ISSOrtholog Curator
Negative regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048387]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Positive regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048386]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Response to retinoic aciddefinition[GO:0032526]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASXL1
GenomeRNAi: 171023
PRO: PR:Q8IXJ9