FAM20C - Extracellular serine/threonine protein kinase FAM20C - human protein (Function)
 
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FAM20C »  Extracellular serine/threonine protein kinase FAM20C   [ EC 2.7.11.1 ]
 
Protein also known as:  Golgi-enriched fraction casein kinase (GEF-CK).
Gene name:  FAM20C
Family name: FAM20
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAOrtholog Compara
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Dentinogenesisdefinition[GO:0097187] silver  
  • IEAOrtholog Compara
Enamel mineralizationdefinition[GO:0070166] silver  
  • IEAOrtholog Compara
Odontoblast differentiationdefinition[GO:0071895] silver  
  • IEAOrtholog Compara
Osteoclast maturationdefinition[GO:0036179] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAGOC
  • IEAUniProtKB KW
Regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040036] silver  
  • IEAOrtholog Compara
Regulation of phosphorus metabolic processdefinition[GO:0051174] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FAM20C
GenomeRNAi: 56975
PRO: PR:Q8IXL6