MSRB3 - Methionine-R-sulfoxide reductase B3 - human protein (Function)
 
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MSRB3 »  Methionine-R-sulfoxide reductase B3   [ EC 1.8.4.- ]  (MsrB3)
 
Gene name:  MSRB3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.  
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  • UniProtKB
Isoform  Iso 2   Is essential for hearing.  
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  • UniProtKB
GO molecular function 
Peptide-methionine (R)-S-oxide reductase activitydefinition[GO:0033743]  
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  • HGNC
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Zinc ion bindingdefinition[GO:0008270]  
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  • HGNC
GO biological process 
Oxidation-reduction processdefinition[GO:0055114]  
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  • UniProtKB KW
Protein repairdefinition[GO:0030091]  
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  • HGNC
Response to oxidative stressdefinition[GO:0006979] silver  
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  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.8.4.-: L-methionine + oxidized thioredoxin L-methionine R-oxide + reduced thioredoxin.  
1
  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 253827
PRO: PR:Q8IXL7