PNPLA6 - Neuropathy target esterase - human protein (Function)
 
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PNPLA6 »  Neuropathy target esterase   [ EC 3.1.1.5 ]
 
Protein also known as:  Patatin-like phospholipase domain-containing protein 6.
Gene name:  PNPLA6
Family name: NTE
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.  
2
  • CuratedUniProtKB
GO molecular function 
Lysophospholipase activitydefinition[GO:0004622]  
  • IEAEC 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Lipid catabolic processdefinition[GO:0016042]  
  • IEAUniProtKB KW
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Phosphatidylcholine metabolic processdefinition[GO:0046470] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.5: 2-lysophosphatidylcholine + H(2)O glycerophosphocholine + a carboxylate.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Glycerophospholipid metabolism  hsa00564+10908  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links