SLX4 - Structure-specific endonuclease subunit SLX4 - human protein (Function)
 
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SLX4 »  Structure-specific endonuclease subunit SLX4
 
Protein also known as:  BTB/POZ domain-containing protein 12.
Gene name:  SLX4
Family name: SLX4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 2
GENE REF ISO

Function

 show evidences
Overview 
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.  
4
  • CuratedUniProtKB
GO molecular function 
Contributes to 3'-flap endonuclease activitydefinition[GO:0048257]  
2
  • IDAUniProtKB
Contributes to 5'-flap endonuclease activitydefinition[GO:0017108]  
3
  • IDAUniProtKB
Contributes to crossover junction endodeoxyribonuclease activitydefinition[GO:0008821]  
3
  • IDAUniProtKB
Enzyme activator activitydefinition[GO:0008047]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
GO biological process 
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
3
  • IDAGOC
  • IEAInterPro 2 GO
DNA double-strand break processing involved in repair via single-strand annealingdefinition[GO:0010792]  
1
  • IMPUniProtKB
DNA repairdefinition[GO:0006281]  
1
  • IMPUniProtKB
DNA replicationdefinition[GO:0006260] silver  
  • IEAInterPro 2 GO
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
2
  • IMPUniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • IMPUniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Response to intra-S DNA damage checkpoint signalingdefinition[GO:0072429]  
1
  • IMPMGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fanconi anemia pathway  hsa03460+84464  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLX4
GenomeRNAi: 84464
PRO: PR:Q8IY92