SRRM1 - Serine/arginine repetitive matrix protein 1 - human protein (Function)
 
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Protein
Gene
References

 
SRRM1 »  Serine/arginine repetitive matrix protein 1
 
Protein also known as:  SR-related nuclear matrix protein of 160 kDa (SRm160).
Gene name:  SRRM1
Family name: Splicing factor SR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.  
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  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nuclear mrna exporter (mrna-e) family  3.A.18.1.1  
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
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  • ICUniProtKB
RNA splicing, via transesterification reactionsdefinition[GO:0000375]  
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  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
mRNA surveillance pathway  hsa03015+10250  
RNA transport  hsa03013+10250  
According to Reactome, this protein belongs to the following pathways:
mRNA 3'-end processing  REACT_1849  
mRNA Splicing - Major Pathway  REACT_467  
Transport of Mature mRNA derived from an Intron-Containing Transcript  REACT_1597  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SRRM1
GenomeRNAi: 10250
PRO: PR:Q8IYB3