GSPT2 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3B - human protein (Function)
 
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GSPT2 »  Eukaryotic peptide chain release factor GTP-binding subunit ERF3B  (eRF3b)
 
Protein also known as:  G1 to S phase transition protein 2 homolog.
Gene name:  GSPT2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  
3
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
mRNA surveillance pathway  hsa03015+23708  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Metabolism of proteins  REACT_17015  
Metabolism of RNA  REACT_21257  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Nonsense-mediated mRNA decay  definition   [KW-0866]
Protein biosynthesis  definition   [KW-0648]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GSPT2
GenomeRNAi: 23708
PRO: PR:Q8IYD1