GPR65 - Psychosine receptor - human protein (Function)
 
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Protein
Gene
References

 
GPR65 »  Psychosine receptor
 
Protein also known as:  T-cell death-associated gene 8 protein.
Gene name:  GPR65
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation-induced cell death or differentiation of T-cells.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • IDABHF-UCL
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IDABHF-UCL
Activation of Rho GTPase activitydefinition[GO:0032862]  
1
  • IDABHF-UCL
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
1
  • IDABHF-UCL
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • IDABHF-UCL
Response to aciditydefinition[GO:0010447]  
1
  • IDABHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPR65
GenomeRNAi: 8477
PRO: PR:Q8IYL9