TRIM22 - E3 ubiquitin-protein ligase TRIM22 - human protein (Function)
 
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TRIM22 »  E3 ubiquitin-protein ligase TRIM22   [ EC 6.3.2.- ]
 
Protein also known as:  Tripartite motif-containing protein 22.
Gene name:  TRIM22
Family name: TRIM/RBCC
Entry whose protein(s) existence is based on evidence at protein level
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1 36 2
GENE REF ISO

Function

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Overview 
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.  
4
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Defense response to virusdefinition[GO:0051607]  
  • IEAUniProtKB KW
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Protein trimerizationdefinition[GO:0070206]  
1
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASPINC
Response to virusdefinition[GO:0009615]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRIM22
GenomeRNAi: 10346
PRO: PR:Q8IYM9