ULK2 - Serine/threonine-protein kinase ULK2 - human protein (Function)
 
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ULK2 »  Serine/threonine-protein kinase ULK2   [ EC 2.7.11.1 ]
 
Protein also known as:  Unc-51-like kinase 2.
Gene name:  ULK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Autophagic vacuole assemblydefinition[GO:0000045] silver  
  • IBARefGenome
Axon extensiondefinition[GO:0048675] silver  
  • IBARefGenome
Negative regulation of collateral sproutingdefinition[GO:0048671] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Regulation of autophagydefinition[GO:0010506]  
1
  • IDAUniProtKB
Response to starvationdefinition[GO:0042594]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
mTOR signaling pathway  hsa04150+9706  
Regulation of autophagy  hsa04140+9706  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Neurogenesis  definition   [KW-0524]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 9706
PRO: PR:Q8IYT8
Chemistry
GuidetoPHARMACOLOGY: 2272