CDK20 - Cyclin-dependent kinase 20 - human protein (Function)
 
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Protein
Gene
References

 
CDK20 »  Cyclin-dependent kinase 20   [ EC 2.7.11.22 ]
 
Protein also known as:  Cyclin-kinase-activating kinase p42.
Gene name:  CDK20
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
1
  • EC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of cell cycledefinition[GO:0051726]  
1
  • EC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23552
PRO: PR:Q8IZL9