ABI1 - Abl interactor 1 - human protein (Function)
 
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Protein
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References

 
ABI1 »  Abl interactor 1
 
Protein also known as:  Spectrin SH3 domain-binding protein 1.
Gene name:  ABI1
Family name: ABI
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.  
2
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Protein tyrosine kinase activator activitydefinition[GO:0030296] silver  
  • IEAOrtholog Compara
GO biological process 
Actin polymerization or depolymerizationdefinition[GO:0008154]  
1
  • NASUniProtKB
Cellular component movementdefinition[GO:0006928]  
1
  • IDAUniProtKB
Lamellipodium morphogenesisdefinition[GO:0072673] silver  
  • IEAOrtholog Compara
Megakaryocyte developmentdefinition[GO:0035855] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAMGI
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABI1
GenomeRNAi: 10006
PRO: PR:Q8IZP0