ABI1 - Abl interactor 1 - human protein (Function)
 
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Protein
Gene
References

 
ABI1 »  Abl interactor 1
 
Protein also known as:  Spectrin SH3 domain-binding protein 1.
Gene name:  ABI1
Family name: ABI
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 224 12
GENE REF ISO

Function

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Overview 
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.  
3
  • UniProtKB
GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
12
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • UniProtKB
Protein tyrosine kinase activator activitydefinition[GO:0030296] silver  
1
  • Ortholog Compara
GO biological process 
Actin polymerization or depolymerizationdefinition[GO:0008154]  
1
  • UniProtKB
Lamellipodium morphogenesisdefinition[GO:0072673] silver  
1
  • Ortholog Compara
Megakaryocyte developmentdefinition[GO:0035855] silver  
1
  • Ortholog Compara
Movement of cell or subcellular componentdefinition[GO:0006928]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • MGI
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
2
  • InterPro 2 GO
  • Ortholog Compara
Somitogenesisdefinition[GO:0001756] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
VEGFA-VEGFR2 Pathway  REACT_264464  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABI1
GenomeRNAi: 10006
PRO: PR:Q8IZP0