CACNA2D3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 - human protein (Function)
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View

CACNA2D3 »  Voltage-dependent calcium channel subunit alpha-2/delta-3
Protein also known as:  Voltage-gated calcium channel subunit alpha-2/delta-3. Cleaved into:  Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3.
Gene name:  CACNA2D3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 3


 show evidences
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit 2 types 1-4 (cca-2) family  8.A.18.3.1  
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IEAOrtholog Compara
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+55799  
Cardiac muscle contraction  hsa04260+55799  
Dilated cardiomyopathy  hsa05414+55799  
Hypertrophic cardiomyopathy (HCM)  hsa05410+55799  
MAPK signaling pathway  hsa04010+55799  
According to Reactome, this protein belongs to the following pathway:
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels  REACT_13606  


Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 55799