CACNA2D3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 - human protein (Function)
 
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CACNA2D3 »  Voltage-dependent calcium channel subunit alpha-2/delta-3
 
Protein also known as:  Voltage-gated calcium channel subunit alpha-2/delta-3. Cleaved into:  Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3.
Gene name:  CACNA2D3
Entry whose protein(s) existence is based on evidence at protein level
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1 20 3
GENE REF ISO

Function

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Overview 
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit 2 types 1-4 (cca-2) family  8.A.18.3.1  
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+55799  
Cardiac muscle contraction  hsa04260+55799  
Dilated cardiomyopathy  hsa05414+55799  
Hypertrophic cardiomyopathy (HCM)  hsa05410+55799  
MAPK signaling pathway  hsa04010+55799  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55799
PRO: PR:Q8IZS8