ABCA7 - ATP-binding cassette sub-family A member 7 - human protein (Function)
 
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ABCA7 »  ATP-binding cassette sub-family A member 7
 
Protein also known as:  Macrophage ABC transporter.
Gene name:  ABCA7
Family name: ABC transporter » ABCA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 2
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.211.10  
GO molecular function 
Apolipoprotein A-I receptor activitydefinition[GO:0034188]  
1
  • Alzheimers_University_of_Toronto
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Contributes to ATPase activitydefinition[GO:0016887]  
1
  • Alzheimers_University_of_Toronto
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626]  
1
  • RefGenome
Cholesterol transporter activitydefinition[GO:0017127]  
1
  • RefGenome
Phospholipid transporter activitydefinition[GO:0005548]  
1
  • RefGenome
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Apolipoprotein A-I-mediated signaling pathwaydefinition[GO:0038027]  
1
  • Alzheimers_University_of_Toronto
Cholesterol effluxdefinition[GO:0033344]  
1
  • Alzheimers_University_of_Toronto
High-density lipoprotein particle assemblydefinition[GO:0034380]  
1
  • Alzheimers_University_of_Toronto
Memorydefinition[GO:0007613]  
1
  • Ortholog Curator
Negative regulation of amyloid precursor protein biosynthetic processdefinition[GO:0042985]  
1
  • Ortholog Curator
Negative regulation of ATPase activitydefinition[GO:0032780]  
1
  • Alzheimers_University_of_Toronto
Negative regulation of beta-amyloid formationdefinition[GO:1902430]  
1
  • Ortholog Curator
Peptide cross-linkingdefinition[GO:0018149]  
1
  • Ortholog Curator
Phagocytosisdefinition[GO:0006909]  
1
  • UniProtKB KW
Phospholipid effluxdefinition[GO:0033700]  
1
  • Alzheimers_University_of_Toronto
Phospholipid scramblingdefinition[GO:0017121]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of ATPase activitydefinition[GO:0032781]  
1
  • Alzheimers_University_of_Toronto
Positive regulation of beta-amyloid clearancedefinition[GO:1900223]  
1
  • Ortholog Curator
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
1
  • Ortholog Curator
Positive regulation of engulfment of apoptotic celldefinition[GO:1901076]  
1
  • Ortholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • Ortholog Curator
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • Ortholog Curator
Positive regulation of phospholipid effluxdefinition[GO:1902995]  
1
  • Ortholog Curator
Protein localization to nucleusdefinition[GO:0034504]  
1
  • Ortholog Curator
Transmembrane transportdefinition[GO:0055085]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+10347  
According to Reactome, this protein belongs to the following pathway:
ABCA transporters in lipid homeostasis  REACT_111158  
 

Keywords

Biological process 
Phagocytosis  definition   [KW-0581]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCA7
GenomeRNAi: 10347
PRO: PR:Q8IZY2