ABRA - Actin-binding Rho-activating protein - human protein (Function)
 
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ABRA »  Actin-binding Rho-activating protein
 
Protein also known as:  Striated muscle activator of Rho-dependent signaling (STARS).
Gene name:  ABRA
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • ISSOrtholog Curator
Transcription coactivator activitydefinition[GO:0003713] silver  
  • IEAOrtholog Compara
GO biological process 
Positive regulation of Rho protein signal transductiondefinition[GO:0035025]  
  • ISSOrtholog Curator
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Protein import into nucleus, translocationdefinition[GO:0000060] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Translocation  definition   [KW-0811]
Transport  definition   [KW-0813]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABRA_(gene)
GenomeRNAi: 137735
PRO: PR:Q8N0Z2