RPTOR - Regulatory-associated protein of mTOR - human protein (Function)
 
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RPTOR »  Regulatory-associated protein of mTOR  (Raptor)
 
Protein also known as:  p150 target of rapamycin (TOR)-scaffold protein.
Gene name:  RPTOR
Family name: WD repeat RAPTOR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 153 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. MTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. MTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). MTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.  
4
  • UniProtKB
GO molecular function 
14-3-3 protein bindingdefinition[GO:0071889]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
22
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
RNA polymerase III type 1 promoter DNA bindingdefinition[GO:0001030]  
1
  • UniProtKB
RNA polymerase III type 2 promoter DNA bindingdefinition[GO:0001031]  
1
  • UniProtKB
RNA polymerase III type 3 promoter DNA bindingdefinition[GO:0001032]  
1
  • UniProtKB
TFIIIC-class transcription factor bindingdefinition[GO:0001156]  
1
  • UniProtKB
GO biological process 
Cell growthdefinition[GO:0016049]  
1
  • UniProtKB
Cellular response to amino acid stimulusdefinition[GO:0071230]  
1
  • UniProtKB
Cellular response to nutrient levelsdefinition[GO:0031669]  
1
  • UniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
1
  • Ortholog Compara
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902]  
1
  • UniProtKB
Positive regulation of TOR signalingdefinition[GO:0032008]  
2
  • UniProtKB
Positive regulation of transcription from RNA polymerase III promoterdefinition[GO:0045945]  
1
  • UniProtKB
Regulation of cell sizedefinition[GO:0008361]  
1
  • UniProtKB
TOR signalingdefinition[GO:0031929]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+57521  
mTOR signaling pathway  hsa04150+57521  
According to Reactome, this protein belongs to the following pathways:
HSF1-dependent transactivation  REACT_264164  
mTOR signalling  REACT_6838  
Regulation of AMPK activity via LKB1  REACT_21285  
Release of eIF4E  REACT_6836  
S6K1-mediated signalling  REACT_6754  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RPTOR
GenomeRNAi: 57521
PRO: PR:Q8N122