RPTOR - Regulatory-associated protein of mTOR - human protein (Function)
 
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RPTOR »  Regulatory-associated protein of mTOR  (Raptor)
 
Protein also known as:  p150 target of rapamycin (TOR)-scaffold protein.
Gene name:  RPTOR
Family name: WD repeat RAPTOR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. MTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. MTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). MTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.  
3
  • CuratedUniProtKB
GO molecular function 
14-3-3 protein bindingdefinition[GO:0071889]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
17
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
RNA polymerase III type 1 promoter DNA bindingdefinition[GO:0001030]  
1
  • IDAUniProtKB
RNA polymerase III type 2 promoter DNA bindingdefinition[GO:0001031]  
1
  • IDAUniProtKB
RNA polymerase III type 3 promoter DNA bindingdefinition[GO:0001032]  
1
  • IDAUniProtKB
TFIIIC-class transcription factor bindingdefinition[GO:0001156]  
1
  • IDAUniProtKB
GO biological process 
Cell growthdefinition[GO:0016049]  
1
  • IMPUniProtKB
Cellular response to amino acid stimulusdefinition[GO:0071230]  
1
  • IMPUniProtKB
Cellular response to nutrient levelsdefinition[GO:0031669]  
1
  • IMPUniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902]  
1
  • IDAUniProtKB
Positive regulation of TOR signalingdefinition[GO:0032008]  
2
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase III promoterdefinition[GO:0045945]  
1
  • IMPUniProtKB
Regulation of cell sizedefinition[GO:0008361]  
1
  • IMPUniProtKB
TOR signalingdefinition[GO:0031929]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+57521  
mTOR signaling pathway  hsa04150+57521  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RPTOR
GenomeRNAi: 57521
PRO: PR:Q8N122