SLC34A3 - Sodium-dependent phosphate transport protein 2C - human protein (Function)
 
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Protein
Gene
References

 
SLC34A3 »  Sodium-dependent phosphate transport protein 2C
 
Gene name:  SLC34A3
Family name: SLC34A transporter
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phosphate:na(+) symporter (pnas) family  2.A.58.1.3  
GO molecular function 
Sodium-dependent phosphate transmembrane transporter activitydefinition[GO:0015321]  
1
  • IDAUniProtKB
Sodium:phosphate symporter activitydefinition[GO:0005436]  
1
  • IDAUniProtKB
GO biological process 
Cellular phosphate ion homeostasisdefinition[GO:0030643]  
1
  • IDAUniProtKB
Phosphate ion transmembrane transportdefinition[GO:0035435]  
1
  • IDAGOC
Phosphate ion transportdefinition[GO:0006817]  
1
  • IDAUniProtKB
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IDAGOC
Sodium ion transportdefinition[GO:0006814]  
1
  • IDAUniProtKB
Sodium-dependent phosphate transportdefinition[GO:0044341] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Type II Na+/Pi cotransporters  REACT_19411  
Note 
A 2:1 stoichiometry to Na(+)/Pi is observed at pH 7.4.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 79 uM for phosphate

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC34A3
GenomeRNAi: 142680
PRO: PR:Q8N130