ADSSL1 - Adenylosuccinate synthetase isozyme 1 - human protein (Function)
 
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ADSSL1 »  Adenylosuccinate synthetase isozyme 1   [ EC 6.3.4.4 ]  (AdSS 1)
 
Protein also known as:  Adenylosuccinate synthetase, muscle isozyme (M-type adenylosuccinate synthetase).
Gene name:  ADSSL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 14 2
GENE REF ISO

Function

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Overview 
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).  
1
  • UniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015] silver  
1
  • Ortholog Compara
Adenylosuccinate synthase activitydefinition[GO:0004019]  
1
  • UniProtKB
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB
GTPase activitydefinition[GO:0003924] silver  
1
  • Ortholog Compara
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB Annot
Phosphate ion bindingdefinition[GO:0042301]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
'de novo' AMP biosynthetic processdefinition[GO:0044208]  
2
  • RefGenome
  • UniPathway
AMP biosynthetic processdefinition[GO:0006167]  
1
  • UniProtKB
Aspartate metabolic processdefinition[GO:0006531] silver  
1
  • Ortholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
1
  • Ortholog Compara
Cellular response to electrical stimulusdefinition[GO:0071257] silver  
1
  • Ortholog Compara
Glutamine metabolic processdefinition[GO:0006541] silver  
1
  • Ortholog Compara
Immune system processdefinition[GO:0002376]  
1
  • UniProtKB
IMP metabolic processdefinition[GO:0046040]  
1
  • RefGenome
Response to muscle activitydefinition[GO:0014850] silver  
1
  • Ortholog Compara
Response to starvationdefinition[GO:0042594] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.4.4: GTP + IMP + L-aspartate GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.  
2
  • HAMAP-Rule
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 1 Mg(2+) ion per subunit.  
2
  • UniProtKB
  • HAMAP-Rule
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2  
2
  • HAMAP-Rule
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+122622  
Metabolic pathways  hsa01100+122622  
Purine metabolism  hsa00230+122622  
According to Reactome, this protein belongs to the following pathway:
Purine ribonucleoside monophosphate biosynthesis  REACT_1776  
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 122622
PRO: PR:Q8N142