ADSSL1 - Adenylosuccinate synthetase isozyme 1 - human protein (Function)
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ADSSL1 »  Adenylosuccinate synthetase isozyme 1   [ EC ]  (AdSS 1)
Protein also known as:  Adenylosuccinate synthetase, muscle isozyme (M-type adenylosuccinate synthetase).
Gene name:  ADSSL1
Entry whose protein(s) existence is based on evidence at protein level
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Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015] silver  
  • IEAOrtholog Compara
Adenylosuccinate synthase activitydefinition[GO:0004019]  
  • IDAUniProtKB
GTP bindingdefinition[GO:0005525]  
  • NASUniProtKB
GTPase activitydefinition[GO:0003924] silver  
  • IEAOrtholog Compara
Magnesium ion bindingdefinition[GO:0000287]  
  • IEAUniProtKB Annot
Phosphate ion bindingdefinition[GO:0042301]  
  • NASUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
'de novo' AMP biosynthetic processdefinition[GO:0044208]  
  • IEAUniPathway
AMP biosynthetic processdefinition[GO:0006167]  
  • IDAUniProtKB
Aspartate metabolic processdefinition[GO:0006531] silver  
  • IEAOrtholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
  • IEAOrtholog Compara
Cellular response to electrical stimulusdefinition[GO:0071257] silver  
  • IEAOrtholog Compara
Glutamine metabolic processdefinition[GO:0006541] silver  
  • IEAOrtholog Compara
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAOrtholog Compara
Immune system processdefinition[GO:0002376]  
  • NASUniProtKB
IMP metabolic processdefinition[GO:0046040] silver  
  • IEAOrtholog Compara
Response to muscle activitydefinition[GO:0014850] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC GTP + IMP + L-aspartate GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion per subunit (By similarity).  
  • CuratedUniProtKB
More information is available from:
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+122622  
Metabolic pathways  hsa01100+122622  
Purine metabolism  hsa00230+122622  
According to Reactome, this protein belongs to the following pathway:
Purine ribonucleoside monophosphate biosynthesis  REACT_1776  


Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 122622
PRO: PR:Q8N142