DOCK4 - Dedicator of cytokinesis protein 4 - human protein (Function)
 
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DOCK4 »  Dedicator of cytokinesis protein 4
 
Gene name:  DOCK4
Family name: DOCK
Entry whose protein(s) existence is based on evidence at protein level
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1 40 4
GENE REF ISO

Function

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Overview 
Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.  
3
  • UniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
1
  • HGNC
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • UniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
1
  • HGNC
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • HGNC
Rac GTPase bindingdefinition[GO:0048365]  
1
  • HGNC
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • UniProtKB
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB KW
GO biological process 
Cell chemotaxisdefinition[GO:0060326]  
1
  • UniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
3
  • GOC
  • InterPro 2 GO
  • UniProtKB KW
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Note 
Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.  
1
  • UniProtKB
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dock4
GenomeRNAi: 9732
PRO: PR:Q8N1I0